<i>Barnesiella intestinihominis</i> improves gut microbiota disruption and intestinal barrier integrity in mice with impaired glucose regulation.

intestinihominis -treated group were Ileibacterium , Allobaculum and Faecalibaculum ( Figure 2H ); the results of the analysis of species differentiation of the GM of the three groups of mice showed that the relative abundance Ligilactobacillus and Muribaculum decreased significantly ( p < 0.05) in the IGR mice, and the relative abundance of Ileibacterium and Lachnoclostridium increased significantly ( p < 0.05); whereas the relative abundance of Ligilactobacillus showed an increasing trend in the B . intestinihominis -treated group after the treatment of B. intestinihominis , the relative abundance of Lachnoclostridium decreased significantly ( p < 0.05) ( Figure 3I ).

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Although not statistically significant, the IPITT AUC values showed a decreasing trend, suggesting improved insulin sensitivity ( Figures 1G–J ).

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