Barely Significant
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Pharmacological inhibition of all known major inward cationic currents does not block the induction of spreading depolarizations.

Front Cell Neurosci · 2025 · PMC12540463 · PMID 41132699

Europe PMCDOI
1
hedged sentence
0.0690
closest p · 1.4× alpha
0.0690
boldest claim

The sentences

nearing significancep = 0.0690so close (0.05 < p ≤ 0.1)
The addition of NiCl 2 (to block calcium currents) to the TTX solution did not block SDs but reduced SD amplitude further in paired recordings in a trend nearing significance (paired t -test, n = 9, p = 0.0690, 3.77 ± 0.88 mV before NiCl 2 application, 2.66 ± 0.64 mV after NiCl 2 application, Table 1 ).

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