Adjuvant FLOT provides survival benefit for oesophagogastric junction and gastric adenocarcinoma patients with low tumour regression after neoadjuvant chemotherapy.

Int J Cancer · 2025 · PMC12541569 · PMID 40693546

Europe PMC DOI

hedged sentences

0.0820

closest p · 1.6× alpha

0.0820

boldest claim

The sentences

a nonsignificant trendp = .082so close (0.05 < p ≤ 0.1)

ypT stage remained an independent risk factor for both endpoints, significantly for PFS (HR 3.379; 95% CI 1.299–8.791; p = .013) and with a nonsignificant trend for OS (HR 2.326; 95% CI 0.900–6.015; p = .082). 3.5 IPTW ‐weighted analysis Following multivariable analysis, an IPTW‐weighted analysis was performed to further reduce confounding.

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marginally significantno p-value reported

In addition, there was a marginally significant difference in the type of surgical procedure, with a higher proportion of oesophagectomies in the ‘no FLOT’ group (90.5%) compared to the other two groups (‘FLOT incomplete’: 63.0%, ‘FLOT complete’: 62.8%).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.