Integrative clinical and molecular insights into the comorbidity between depression and sleep apnea syndrome.

OSA severity level demonstrated a marginal association with depression (F(2) = 3.847, p = 0.068), suggesting a possible trend that warrants further investigation with a larger sample size. 3.2.

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As illustrated in Figure 2A , this overlap is highly significant, with a Fisher’s exact test revealing an odds ratio (OR) of 11 and a p-value of 4.95 × 10 -319 ( Figure 2 ), indicating a substantial enrichment of common genes between Depression and Sleep Apnea Syndrome.

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