We also tested whether the decrease in IL-1β release upon CLIC1 blockade may involve actin-binding ERM proteins, since actin-dependent processes can modulate NLRP3 function ( 52 ), but we only observed a nonsignificant trend toward lower IL-1β levels upon blockade of ERM proteins with NSC (fig.
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The chloride intracellular channel 1 (CLIC1) is essential for microglial morphodynamics and neuroinflammation.
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