Time-Intensity Curve parametric imaging as a novel quantitative biomarker: enhancing diagnostic accuracy and inter-rater reliability in prostate cancer ultrasound.

The Cochran-Armitage test for trend confirmed a highly significant trend (Z = 5.5578, p < 0.001), indicating that as the spatial heterogeneity of perfusion (discreteness grade) increases, the probability of a malignant diagnosis rises monotonically. 3.3.

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