The effects of melatonin on oxidative stress, inflammation, apoptosis and Nrf2/HO-1 in acrylamide-induced lung injury in rats.

Naunyn Schmiedebergs Arch Pharmacol · 2025 · PMC12552338 · PMID 40402233

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NF-κB plays a key role in the gene regulation and activation of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6, COX-2, and iNOS, making it a highly significant therapeutic signaling pathway (Caglayan et al. 2018 ; Sengul et al. 2021 ).

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