PS3N: leveraging protein sequence-structure similarity for novel drug-drug interaction discovery.

For the DrugBank dataset, the PS3N model showed highly significant improvements in Precision and Recall (both with p < 0.05), confirming the model’s strength in accurately classifying interactions.

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Because the differences may not be significant, drugs may work in a non-specific manner, altering both normal and unwanted processes–these results in unfavorable side effects.

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