Comparative effectiveness and safety of tenecteplase versus alteplase for intravenous thrombolysis in acute ischemic stroke: a retrospective study.

In patients younger than 80 years (mRS 0–2: aOR, 1.52; 0.84–2.77; p = 0.166) and without stroke history (aOR, 1.60; 0.85–3.06; p = 0.152), tenecteplase therapy was associated with a nonsignificant trend toward better functional outcomes at 90 days.

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Discussion In this retrospective comparative analysis, treatment with tenecteplase was associated with an observed trend toward increased likelihood of achieving functional independence at 90 days compared with alteplase.

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