Integrative GWAS and RNA-Seq analysis for target identification and virtual drug screening in colorectal cancer.

Were all genes in the human genome used as background, or a more relevant subset (e.g., all genes expressed in colon/rectal tissue)? The adjusted p-values for many terms in Table 3 and Table 4 are relatively high, suggesting marginal significance despite being "top 10." The conclusions drawn from these enrichment results should be very carefully tempered. 10.

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