Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop.

Mice transplanted with Piezo1 KO bone marrow (BMT-KO) began to show a decreasing trend in body weight at 4 weeks after bone marrow transplantation compared to those transplanted with WT bone marrow (BMT-WT) (Fig. 3d ), whereas the fat percentage and oxygen consumption did not differ between these two groups of mice (supplementary Fig. 10c, d ).

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