PRDX5 Regulates Mitochondrial Function and Nuclear Spreading in Myogenesis and Acts With PRDX3 to Delay Muscle Aging.

Similarly, the expression of Trak1 , which encodes Milton, exhibited an increasing trend during in vitro myotube formation and was significantly elevated in regenerating muscle tissue in vivo at 7 and 14 days after injury (dpi) (Figure 5B ).

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The expression of mitochondrial fusion markers, particularly Mfn2 , showed a decreasing trend in Prdx5 ‐deficient myotubes, while mitochondrial fission markers remained unchanged (Figure S1 ).

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