Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype.

We found that the DHA/ACOX1i combo treatment was associated with (i) the acquisition of a punctate ER morphology as previously reported in cells undergoing unfolded protein response (UPR) [ 36 ] (Figure 4F ; Figure S4F , Supporting Information), (ii) an increase in the fluidity of the ER membranes (ie, reduction in GP) as determined by combining fluorescent Laurdan and ER‐tracker dye detection (Figure 4G ; Figure S4G , Supporting Information) and (iii) a highly significant increase in the expression of CHOP, a key transcription factor activated during ER stress and mediating apoptosis (Figure 4H,I ; Figure S4H,I , Supporting Information).

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