Urinary Tract Infections in a Single-Center Bulgarian Hospital: Trends in Etiology, Antibiotic Resistance, and the Impact of the COVID-19 Pandemic (2017-2022).

Symptomatic uncomplicated cystitis (women): Counts as low as ≥10 2 –10 3 CFU/mL may be significant (e.g., for E. coli , Staphylococcus saprophyticus ) when clinically concordant. 3.

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When carbapenem resistance was assessed by pooling imipenem and meropenem, a marked and highly significant upward trend was identified in K. pneumoniae (+8.88 percentage points per year; 95% CI 8.60 to 9.15).

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