Epicatechin Protects Against Post-Cardiac Arrest Brain Injury in Aged Rats via NRG1-Mediated Suppression of Neuroinflammation.

Curr Issues Mol Biol · 2025 · PMC12562848 · PMID 41150741

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The present study extended the anti-aging effect of EC in 21-month-old rats, which demonstrated a significant augment in the expression levels of pro-inflammatory cytokines IL-1β and IL-6 with a trend toward elevated TNF-α levels, whereas a decreasing trend of the anti-inflammatory cytokine IL-10 in comparison with 3-month-old rats.

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