An In Vivo Drug Screen Reveals That Sirtuin 2 Activity Promotes Spinal Cord Neurogenesis in Developing Zebrafish.

Of the 10 hits identified after the two-step drug screen, 2 drugs caused a highly significant ( p < 0.0001) reduction in the number of serotonergic neurons ( Table 1 ): SirReal2 ( Figure 1 a,b and Supplementary File S2 ) and reserpine ( Supplementary File S2 ).

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