Benzoxazine-Purine Hybrids as Antiproliferative Agents: Rational Design and Divergent Mechanisms of Action.

In HCT-116 cells, both 9 and 12 induced a highly significant reduction in the G 1 /G 2 fraction, with concomitant decreases in G 2 /M from 8.37% in controls to 6.67% following 9 treatment (not statistically significant) and to 5.53% with 12 ( p < 0.01) ( Figure 6 A–C,G).

also in 132,142 other papers