Approaching therapy of Alzheimer's disease via the antidiabetic drug liraglutide-a study with streptozotocin intracerebroventricularly treated Wistar rats.

J Neural Transm (Vienna) · 2025 · PMC12568868 · PMID 40646278

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hedged sentences

0.0010

closest p · 0.0× alpha

0.0630

boldest claim

The sentences

highly significantp = 0.001actually significant

In consequence of a highly significant main effect of effect of STZ treatment ( F (1,25) = 12.715, p = 0.001) and a significant interaction between STZ and LIR treatment ( F (1,25) = 10.075, p = 0.004), subsequent Bonferroni multiple comparison tests revealed that Glut1 relative expression levels were reduced in the STZ/SAL group compared to the VEH/SAL group with high significance (p = 0.0002) and that after LIR treatment Glut1 mRNA levels were significantly increased in the STZ group (STZ/SAL vs.

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marginally significantp = 0.063so close (0.05 < p ≤ 0.1)

Three-way mixed ANOVA yielded only a marginally significant time × group × treatment interaction ( F (1,25) = 3.781, p = 0.063; Fig. 3 ).

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