Follicular helper T cells (Tfh): heterogeneity in spatial distribution and phenotypic characteristics.

However the findings of tumor-infiltrated Tph that do not secrete IL-21 but instead recruit Breg cells by providing TGF-β and PD-L1 challenges this unified view ( 138 ), these cells may not have the same origin with Tph in inflammary tissues, but it is also rational to reason that it is within the tumor microenvironment that Tph changes its state or become a new subset, and it could be valuable to compare this Tph with “bona-fide” Tph on the a larger panel of Tph signatures, tracking how Tph enter these pathogenic tissues may be significant in further illustrating Tfh and Tph relationship. 3.2.

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