Association between ancestry and tumor somatic mutations in a large national cohort of women with breast cancer.

NPJ Breast Cancer · 2025 · PMC12572180 · PMID 41162424

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highly significantno p-value reported

The two most common and highly significant copy number alterations seen in this ancestry group were MYC ( n = 1528; odds ratio (OR) = 1.58; FDR = 2.75 × 10 −19 ), which was associated with ER-negative breast cancer, and FGFR1 ( n = 889; OR = 1.62; FDR = 9.48 × 10 −16 ), which was associated with ER-positive breast cancer.

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