Dynamic alterations of lymphocyte subsets following sepsis in octogenarian and elder patients.

In elder and octogenarian patients, the immunosenescence status proved that the antimicrobial response to invading pathogens was damaged, leading to an increasing trend of secondary infections in persistently decreasing CD3 + T cells following sepsis.

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This study also showed that early adaptive immune suppression with a decreasing trend of CD3 + T-cell alterations following sepsis was associated with poor outcomes in patients of elder group (65–79 years) and octogenarian group (≥80 years).

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