Barely Significant
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Acetaminophen interactions with immune checkpoint inhibitors: guilt by association?

J Immunother Cancer · 2025 · PMC12574408 · PMID 41161820

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highly significantno p-value reported
Finally, the magnitude of decreased OS and PFS reported in both studies was highly significant, with a decrease of more than 50% in the median OS and PFS associated with acetaminophen, 2 and increased risks of these events by 33% to 66% (HRs of 0.34–0.67) ( table 1 ).

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