A catalog of stability-associated sequence elements in 3' UTRs of yeast mRNAs.

On the other hand, among genes subjected to Type II regulation, which are predicted to be regulated only at the mRNA degradation level, we only found barely significant enrichments (which did not pass the FDR-requirement), for example, for 'RNA modification' ( p -value = 0.0029), 'protein modification' ( p -value = 0.01) and 'nucleic-acid metabolism' ( p -value = 0.022) (see our supplementary data [ 16 ]).

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For example, M32 is located in the 3' UTR of only six genes, but is associated with an extremely high mean half-life of 84 mins, and thus was found to be highly significant.

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When analyzing the evolutionary conservation of these 23 localization motifs in the sensu stricto yeasts, we found that nine are extremely significantly conserved, while one more shows a borderline significance in its conservation (see examples in Figure 7 and the full catalog [ 16 ]).

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