Small Extracellular Vesicles From Radioresistant H3K27M-Pediatric Diffuse Midline Glioma Cells Modulate Tumor Phenotypes and Radiation Response.

We validated the top five upregulated genes from RNA‐seq using qPCR, each showing an increasing trend in expression after RR‐sEV treatment compared to control (Figure S9A ) with NDUFA6 showing a significant increase upon RR‐sEV treatment ( p < 0.05) This enrichment pattern, driven largely by mitochondrial and electron transport chain‐associated genes, reinforces a role for mitochondrial reprogramming.

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RS‐Clone 1‐CCM did not significantly alter viability compared to the parental SF7761 CCM, though a mild trend was observed.

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