highly significantp < 0.0001
We conducted a sphere formation assay on agarose-coated plates, which minimized cell adherence to the surface, and observed a highly significant increase ( p < 0.0001) in the number of spheres formed in the groups; BDFO and BNFO, respectively, as compared to the control group, BNFN whereas FDBO and FNBO cells did not show any considerable change (Fig. 4 a, b ).