The conditional analysis was motivated by several factors: (1) the presence of a highly significant association signal on BTA22 in the MITF region, a well-established candidate gene for pigmentation traits across multiple species (Negro et al. 2017 ; Petersen et al. 2023 ; Wen et al. 2024 ); (2) the need to determine whether associations on other chromosomes were independent or potentially driven by linkage disequilibrium with the BTA22 signal; and (3) the importance of characterizing the true genetic architecture underlying depigmentation in Nellore cattle.
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Beyond black and white: dissecting the genetic basis of skin depigmentation in Nellore cattle.
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