Independent validation of lung adenocarcinoma prognostic risk scores incorporating cholesterol and estrogen metabolism related transcriptional biomarkers.

Sci Rep · 2025 · PMC12578827 · PMID 41174058

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a decreasing trendno p-value reported

Finally, we validated in the Memorial Sloan Kettering Cancer Center corhort ( GSE248249 ) and Sjöberg Immune Checkpoint Inhibition cohort ( GSE283829 ) that Cholescore was significantly decreased after PD-L1 treatment; additionally, compared with lung cancer patients with disease progression, those with stable disease also showed a decreasing trend in Cholescore (Fig.

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