Barely Significant
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Metformin's protection against blood-brain barrier disruption and neuronal dysfunction under oxygen-glucose deprivation and tobacco smoke and e-vape chemical exposure.

Fluids Barriers CNS · 2025 · PMC12581476 · PMID 41185023

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a decreasing trendno p-value reported
Nevertheless, we identified a significant decrease ( p < 0.0001) in the MFI of claudin-5 after OGD/R and a decreasing trend in ZO-1 and occludin intensity, which were abrogated with MF pretreatment (Fig. 4 B-E).

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