Mendelian Randomization Studies of Myopia: Choosing the Right Summary Statistics.

For instance, the MR analyses using the original and transformed versions of the GWAS summary statistics ukb-a-419 from the Neale lab repository suggested a highly significant negative causal relationship between years spent in full-time education and myopia status, albeit with different magnitudes (using the original dataset, OR = 0.99 per year of education; 95% CI, 0.988–0.996; P = 1.7e-05; using the transformed dataset, OR = 0.89 per year of education; 95% CI, 0.85–0.94; P = 1.5e-05), implying that additional education was protective against myopia.

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