HIF2α negatively regulates MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastoma.

Proc Natl Acad Sci U S A · 2025 · PMC12582314 · PMID 41118218

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Despite several hundred bulk RNA-sequenced/arrayed neuroblastoma tumors exhibiting a highly significant correlation between high levels of EPAS1 expression and low-risk tumors with favorable outcome ( 7 ), some studies have continued to argue that HIF2α acts to fuel tumor growth, partly by imposing an immature state with stem cell–like features that blocks differentiation ( 5 , 11 – 15 ).

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