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Spatial-temporal characteristics and prediction of ischemic heart disease burden in the working population aged 15 to 59 years in China.

Front Cardiovasc Med · 2025 · PMC12583029 · PMID 41195127

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a decreasing trendno p-value reported
an increasing trendno p-value reported
The period effect showed that, taking 2002–2006 as the reference period (RR = 1.00), the national incidence risk from 1992–2021 presented an increasing trend first and then a decreasing trend, and the period with the highest risk was 2007–2011 (RR = 1.02, 95% CI: 0.95–1.09).

also in 47,180 other papers

an obvious trendno p-value reported
With the rapid development of the social economy and the transformation of lifestyle, the disease burden of IHD is still constantly rising, and the age of onset shows an obvious trend of getting younger.

also in 1,006 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.