Prenatal exposure to endocrine disrupting chemicals and the association with behavioural difficulties in 7-year-old children in the SELMA study.

10 for the girls, MBP is significant after correcting with the false discovery rate, which indicates that MBP is highly significant and important potentially even in single chemical analysis.

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However, girls showed 87/100 positive betas for quasipoisson and 94/100 positive betas for logistic WQS regression models, indicating a borderline association, as also the logistic regression models using 100 repeated holdout validations were close to significance (OR 1.31, 95% CI 0.93, 1.85).

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In the WQS sex-stratified interaction regression models, the girls showed significantly increased ORs (OR 1.77, 95% CI 1.67, 1.87) whereas the boys show borderline significance (OR 1.33, 95% CI 0.99, 1.78).

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Using WQS regression as a supervised strategy for characterising the mixture effect of the EDCs, and more specifically, in a stratified interaction model, we were able to detect at least a borderline significant positive (adverse) association for girls.

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