Sleep quality during preparation for RAI: recombinant TSH vs. levothyroxine withdrawal.

Analysis by gender revealed that men in the LT4-W group were more anxious/depressed than their rhTSH counterparts, and that their impaired sleep quality was more dependent on these psychological than on hormonal variables (statistical correction of the PSQI components for hormonal parameters led to marginally significant differences between the subgroups, while correction for HADS scores completely abolished the differences).

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In men, the two subgroups differed in only two PSQI components (subjective quality and global score), and there was marginal significance between groups after correction for hormonal levels, possibly due to the small number of male patients.

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