Evaluation of HIV-1 DNA resistance evolution in highly treatment-experienced and multi-resistant individuals under suppressive antiretroviral therapy: a longitudinal study from the PRESTIGIO Registry.

The overall mutation burden of M41L decreased from T0 to T1 with a trend towards significance ( P = 0.093), regardless of NRTI pressure (Figure 2c ), and mutation clearance was not associated with T0 mutational load levels (Figure 2d ).

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