Meta-analysis reveals differences in somatic alterations by genetic ancestry across common cancers.

Nat Genet · 2025 · PMC12597819 · PMID 41102416

Europe PMC DOI

hedged sentence

0.0890

closest p · 1.8× alpha

0.0890

boldest claim

The sentences

marginally significantP = 0.089so close (0.05 < p ≤ 0.1)

CDK12 inactivating mutations were enriched in EAS ancestry in prostate cancer (Supplementary Table 1 ) and were marginally significant after adjusting for metastatic status available in the MSK-IMPACT cohort only ( P = 0.089, OR = 2.195).

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