PolyGR-containing aggregates link with pathology and clinical features of Alzheimer's disease.

Quantification shows a positive trend in polyGR+ aggregate levels in AD cases with CERAD scoring neuritic plaques from “none” to “sparse” to “moderate” and “frequent”, in which AD cases with CERAD scores of “frequent” showed significantly increased polyGR+ aggregate levels compared to those without neuritic plaques (CERAD scores = none) ( p = 1.13 × 10 −4 ) (Fig. 3 h).

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