Pan-cancer multi-omics analysis reveals IQCE as a malignant cell-restricted oncogenic biomarker driving immunosuppression and chemoresistance in cutaneous melanoma.

Discov Oncol · 2025 · PMC12602738 · PMID 41212279

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

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boldest claim

The sentences

borderline significancep = 0.06so close (0.05 < p ≤ 0.1)

For disease-free interval (DFI), significant protection was observed in esophageal carcinoma (ESCA: HR = 0.515, 0.312–0.850, p = 0.01), contrasting with elevated risk in LGG (HR = 3.498, 1.279–9.569, p = 0.015) and borderline significance in diffuse large B-cell lymphoma (DLBC: HR = 10.957, 0.904–132.845, p = 0.06)(Fig. 4 D).

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