Piwil-2 represents a poor prognosticator in Merkel cell carcinomas that regulates oncoproteins, cell cycle arrest and SOX-2 expression.

However, although our data fit well with both major MCC pathways, on the one hand TRRAP and BRD8 to the ST-MYCL-EP400 pathway (MYCL) and, on the other hand, ORC4 and PRIM2 to E2F transcription factors and cell cycle control (cell cycle), our subsequent analyses were not as significant as expected.

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