Barely Significant
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The global, regional, and national burden of early, middle, and late-onset esophageal cancer and trends from 1990 to 2021: a systematic analysis of the Global Burden of Disease Study 2021.

J Thorac Dis · 2025 · PMC12603433 · PMID 41229786

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a decreasing trendno p-value reported
The temporal trends were similar in ASMR and ASDR, with regions across different SDI levels all showing a decreasing trend between 1990 and 2021.

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