a trend toward significancep = 0.0625
These results indicate that the miRNA combinations show markedly stronger predictive performance in patients within the extreme (average AUC ~ 0.8) CAPRA risk category compared to the moderate group (average AUC ~ 0.54), with a statistically significant difference by paired t ‐test ( p < 0.001) and a trend toward significance by non‐parametric testing ( p = 0.0625, Wilcoxon) (Figure 6C ).