A novel approach to establish orthotopic right lung transplantation in rats.

1 , 2 As the International Society for Heart and Lung Transplantation (ISHLT) reported in 2021, more than 5,000 LTx procedures have been performed worldwide, and an increasing trend has been maintained annually. 3 The development of various animal models has contributed to investigations into the complications associated with lung transplantation, such as ischemia/reperfusion injury and chronic lung allograft dysfunction. 4 , 5 , 6 , 7 , 8 , 9 , 10 Among these models, rats are superior in terms of the balance between cost and physical similarities to humans. 11 The orthotopic rat left LTx model is widely adopted by researchers.

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