Does Amyotrophic Lateral Sclerosis (ALS) Have Metabolic Causes from Human Evolution?

In reverse, CMAH deletion in mice has major peripheral metabolic effects, with a higher maximal respiratory capacity and an improved skeletal muscle capacity for oxygen use which lead to a highly significant increases in time running on a forced treadmill for untrained animals and in time voluntarily wheel running [ 56 ], consistent with the role in human evolution.

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