Characterization of Ceramide Kinase from Basolateral Membranes of Kidney Proximal Tubules: Kinetics, Physicochemical Requirements, and Physiological Relevance.

Int J Mol Sci · 2025 · PMC12610059 · PMID 41226412

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BLM-associated CerK activity exhibits an optimum pH between 6.5 and 7.2, leading to maximum enzyme activity and C1P formation (~120 fmol × mg −1 × min −1 ) ( Figure 5 A), revealing a highly significant effect of pH on CerK activity.

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