Cortical Tubers' Transformation in Pediatric Patients Diagnosed with Tuberous Sclerosis Complex: A Retrospective Longitudinal MRI Analysis.

J Clin Med · 2025 · PMC12610563 · PMID 41227061

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highly significantno p-value reported

This analysis confirmed a significant increase over time: the mean number of CTs rose from 16.11 ± 12.43 at baseline to 18.77 ± 13.29 at follow-up, yielding a mean paired difference of −2.67 (95% CI [−3.94, −1.39]); the test statistic was t (56) = 4.19, corresponding to p < 0.0001, indicating a highly significant increase in overall tuber burden.

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