Calcium-dependent cooperativity and stability of Titin's tandem I82-I83 domains.

Protein Sci · 2025 · PMC12611880 · PMID 41229035

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might be significantno p-value reported

However, these domains are within the I‐band region of titin, which is extended when a muscle is elongated and therefore both domain orientations might be significant.

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might not be significantno p-value reported

This difference in domain orientation might not be significant for many multidomain proteins that don't experience mechanical force.

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