All but one of the wee mutants tested showed a highly significant reduction ( p -value < < 0.001; one-tailed t -test) in cell size, of about ~ 10%, after addition of JBIR-141/Zn 2+ .
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The zinc bound form of the actinomycete derived natural product compound JBIR-141 induces a mitotic phenotype in fission yeast.
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