Letter to the Editor: Comment on " Is Site of Radiation Therapy Associated With Pathologic Complete Response in Patients With Locally Advanced Esophageal Cancer?"

For instance, clinically node-positive (cN + ) disease, a well-recognized adverse prognostic factor, was more frequent in the HVC group (72% vs 61%; P = .002), and although this difference attenuated to a statistical trend ( P = .10) after adjustment, the directional imbalance suggests that HVCs treated patients with more advanced nodal disease.

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