Effect of external cues on clock-driven protection from influenza A infection.

Further pathway analysis revealed that while those involved in innate activation (granulocyte diapedesis, IL-15 signaling, cytokine storm) were upregulated in the ZT23(LL) group relative to the ZT23 group, the most highly significant pathways involved innate to adaptive communication (communication between innate and adaptive cells) and activation of the adaptive immune system (B cell activation as in systemic lupus, altered T and B cells signaling, NFAT signaling) ( Figure 5D ).

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