Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities.

To define a locus associated with increased adiposity and protective effects on cardiometabolic traits, we retained only variants for which the single-trait GWASs for both traits reached marginal significance, defined as P < 10 −4 , and for which the association was opposite to the established phenotypic correlation.

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