Thermodynamic stability modulates chaperone-mediated disaggregation of α-synuclein fibrils.

Chem Sci · 2026 · PMC12622358 · PMID 41257205

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a decreasing trendno p-value reported

The disaggregation efficiency exhibited a decreasing trend with fibril maturation time for all three repeats of F65 and one repeat of F91, and no apparent dependency for Fm ( Fig. 3b ).

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